BackgroundPlagiarism is common and threatens the integrity of the scientific literature. However, its detection is time consuming and difficult, presenting challenges to editors and publishers who are entrusted with ensuring the integrity of published literature.MethodsIn this study, the extent of plagiarism in manuscripts submitted to a major specialty medical journal was documented. We manually curated submitted manuscripts and deemed an article contained plagiarism if one sentence had 80 % of the words copied from another published paper. Commercial plagiarism detection software (...) was utilized and its use was optimized.ResultsIn 400 consecutively submitted manuscripts, 17 % of submissions contained unacceptable levels of plagiarized material with 82 % of plagiarized manuscripts submitted from countries where English was not an official language. Using the most commonly employed commercial plagiarism detection software, sensitivity and specificity were studied with regard to the generated plagiarism score. The cutoff score maximizing both sensitivity and specificity was 15 % (sensitivity 84.8 % and specificity 80.5 %).ConclusionsPlagiarism was a common occurrence among manuscripts submitted for publication to a major American specialty medical journal and most manuscripts with plagiarized material were submitted from countries in which English was not an official language. The use of commercial plagiarism detection software can be optimized by selecting a cutoff score that reflects desired sensitivity and specificity. (shrink)

These original essays by seven leading contemporary political philosophers spanning the political spectrum explore the possibility of achieving agreement in political theory. Each philosopher defends in a principal essay his or her own view of social justice and also comments on two or more of the other essays. The result is a lively exchange that leaves the reader to judge to what degree the contributors achieve agreement or reconciliation.

DNA methylation is a repressive epigenetic mark vital for normal development. Recent studies have uncovered an unexpected role for the DNA methylome in ensuring the correct targeting of the Polycomb repressive complexes throughout the genome. Here, we discuss the implications of these findings for cancer, where DNA methylation patterns are widely reprogrammed. We speculate that cancer‐associated reprogramming of the DNA methylome leads to an altered Polycomb binding landscape, influencing gene expression by multiple modes. As the Polycomb system is responsible for (...) the regulation of genes with key roles in cell fate decisions and cell cycle regulation, DNA methylation induced Polycomb mis‐targeting could directly drive carcinogenesis and disease progression.Editor's suggested further reading in BioEssays Unmasking risk loci: DNA methylation illuminates the biology of cancer predisposition Abstract. (shrink)

Many adoptees face a number of challenges relating to separation from biological parents during the adoption process, including issues concerning identity, intimacy, attachment, and trust, as well as language and other cultural challenges. One common health challenge faced by adoptees involves lack of access to genetic-relative family health history. Lack of GRFHx represents a disadvantage due to a reduced capacity to identify diseases and recommend appropriate screening for conditions for which the adopted person may be at increased risk. In this (...) article, we draw out common features of traditionally understood “health disparities” in order to identify analogous features in the context of adoptees’ lack of GRFHx. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

Seeing philosophy as conversation with a number of fruitful avenues of discourse, Rorty seems to be caught in limbo, unwilling to follow through or commit himself to any particular line of discourse for fear of closing himself off to alternative discourses. Choosing to adopt this particular attitude he still has made a choice: he has made a commitment to non-commitment, or as Ortega puts it, “decided not to decide.” Jose Ortega y Gasset, The Revolt of the Masses, trans. anonymously (New (...) York: W.W. Norton & Company, 1957), p. 48. Such a commitment or decision is in no way neutral, for it attempts to enforce, by moral requirement, Richard Rorty, Philosophy and the Mirror of Nature, p. 394. a new vocabulary which views philosophy as conversation between speakers, with a whole range of obligations and implications included. Thus the Rortian alternative, like the alternatives he criticizes, plays the role “of the cultural overseer who knows everyone's common ground — the Platonic philosopherking who knows what everybody else is really doing whether they know it or not, because he knows about the ultimate context ... within which they are doing it.” Ibid., pp. 317–318. In fact, Rorty even refers to “conversation as the ultimate context” Ibid., p. 389. In assuming to know everyone's common ground, that every-one is participating in the conversation of humankind whether they realize it or not, Rorty seems to fall prey to a similar “self-deceptive ... absurdity of thinking that the vocabulary [he uses] ... has some privileged attachment to reality which makes it more than just a further set of descriptions.” Ibid., p. 361.One implication of such a position is that despite its holder's claims that he or she will at least attempt to incorporate abnormal discourses of all sorts, the conversationalist will not be able to consider seriously a number of types of discourse. If the edifying, hermeneutical philosopher were really “willing to pick up the jargon of the interlocutor rather than translating it into his own terms,” Ibid., p. 318. it would often be necessary to drop the notion of conversation as being a fundamental practice or moral obligation. Rorty is obviously unwilling to really pick up the jargon of the epistemologist and the meta-physician he criticizes, or of Nietzsche and Stirner, for each of these does not have contained within them, at least as a primary consideration, the continuing of the conversation of humankind. Because he imposes his vocabulary and descriptions on them - they are merely speakers in a conversation - he will see them as merely threads in a larger social fabric, he will be translating their “jargon” into his own, and thus will never be able to take their position seriously, never be prepared to adopt their position as his own. Being possessed by the notion of continuing the conversation, he is closing himself off to traditional epistemological and metaphysical projects, as well as to the perspectives of thinkers like Stirner and Nietzsche, despite his claim to be open to all of them. He can only consider them as topics of conversation as long as he remains committed to conversation, and thus never consider them as live options, or consider them as alternative life-projects to be pursued on their own terms. In insisting on the moral obligation of philosophers to continue the conversation of the West, he is insisting on the moral obligation of philosophers not to whole-heartedly adopt any of the alternatives which would tend to close off this conversation. Therefore, instead of decrying “the very notion of having a view, while avoiding having a view about having views,” Ibid., p. 371. Rorty has a rather clear view about having views: one should not hold any view whole-heartedly except the view that philosophy should be conversation, and this conversation should be the way to decide among views; that is, the way to decide among all views except the view that conversation should be the way to decide, which for Rorty is not open to discussion, but is a moral obligation. All perspectives are encouraged in the conversation, but the conversational morality has already prescribed that these views should not be whole-heartedly adopted by responsible individuals. Requiring that philosophy be conversation, Rorty closes off numerous possible life-styles, and almost all traditional philosophical projects: he merely saves the appearances of these alternatives. Morally required to continue the conversation, philosophy becomes just talk. Along the same lines, when Rorty claims that the normal and abnormal discourses “do not compete, but rather help each other out,” Ibid., p. 346. he assumes that the epistemological and metaphysical discourses will be helped by various abnormal discourses, and assumes thinkers like Nietzsche and Stirner will be helped by being made to see the significance of societies which have fallen together and are united by civility. Yet, in doing this, Rorty is not attempting to understand - either sympathetically or intellectually - what it would mean to help these projects on their own terms, and as such is not trying to understand and assimilate these alternatives as he claims he is. Rather, he is holding each of these alternatives up to his own ideal of an “open conversation,” and judging what it would mean to “help out” these alternatives only according to his own particular standards. In continually translating what others are offering into his own particular frame of reference, he does not appreciate these philosophical alternatives for their worth as individual activities which can contribute to life and/or society, but values them only for what they can contribute to his larger project, the conversation of humankind. However, if these alternatives were taken seriously, then they would surely be seen to compete with his view which advocates social criteria for adjudicating disputes, thereby denying many of the fundamental aspects of the above-mentioned alternative philosophical under-takings. It should be seen that contrary to what Rorty suggests, edification also “provides only some, among many, ways of describing ourselves,” Ibid., p. 361. and is only one type of human project among many others. In suggesting that we shift our focus “from the relation between human beings and the objects of their inquiry to the relation between alternative standards of justification, and from there to the actual changes in these standards which make up intellectual history,” Ibid., pp. 389–390. Rorty neither breaks free from traditional concerns, nor brings the focus of attention onto our own lives. As Bernstein notes, “there is a sense in which Rorty himself is obsessed. It is almost as if he can't quite ‘let go’ and accept the force of his own critique. It is as if Rorty himself has been more deeply touched by what he is attacking than he realizes.... He himself is obsessed with the obsessions of philosophers.” R.J. Bernstein, “Philosophy in the Conversation of Mankind,” pp. 767, 775.As a result of this, Richard Eldridge correctly notes that Rorty is unable to realize that “[c]riticism matters just insofar as it enables us fruitfully to develop our lives and our practices out of the past.” Richard Eldridge, “Philosophy and the Achievement of Community: Rorty, Cavell and Criticism,” Metaphilosophy 14, No. 2 (1983), p. 124. As an alternative to the Rortian attitude, I invite the reader to entertain a perspective which is not primarily concerned with identifying oneself in accordance with, or in opposition to, particular traditions, but rather with assimilating and utilizing all previous philosophical labors in order to achieve the greatest appreciation of one's own personal possibilities, and the fullest expression of one's own powers. (shrink)

Dimensions of character are often overlooked in professional practice at the expense of the development of technical competence and operational efficiency. Drawing on philosophical accounts of virtue ethics and positive psychology, the present work attempts to elevate the role of ‘good’ character in the professional domain. A ‘good’ professional is ideally one that exemplifies dimensions of character informed by sound judgement. A total of 2340 professionals, from five discrete professions, were profiled based on their valuation of qualities pertaining to character (...) and judgement. Profile differences were subsequently examined in the self-reported experience of professional purpose towards a wider societal ‘good’. Analysis of covariance, controlling for stage of career, revealed that professionals valuing character reported higher professional purpose than those overweighting the importance of judgement or valuing neither character nor judgement, F = 7.92, p <.001. No differences were found between the two groups valuing character, irrespective of whether judgement was valued simultaneously. This profiling analysis of entry-level and in-service professionals, based on their holistic character composition, paves the way for fresh philosophical discussion regarding what constitutes a ‘good’ professional and the interplay between character and judgement. The empirical findings may be of substantive value in helping to recognise how the dimensions of character and judgement may impact upon practitioners’ professional purpose. (shrink)

Researchers typically attempt to fulfill disclosure and informed consent requirements by having participants read and sign consent forms. The present study evaluated the reading levels of informed consent forms used in psychology research and other fields (medical research; social science and education research; and health, physical education, and recreation research). Two standardized measures of readability were employed to analyze a randomly selected sample (N = 108) of informed consent forms used in Institutional Review Board-approved research projects at a midwestern university (...) during the 1987-1988 academic year. Results indicate that informed consent forms are typically written at a higher reading level than is appropriate for the intended population and that there are no consistently significant differences in readability among areas of research or between college student and noncollege student participants. Due to the unacceptably high reading level of the consent forms, one must question whether participants can comprehend the information contained in the consent forms. (shrink)

We argue that the propositional and link-based approaches to human contingency learning represent different levels of analysis because propositional reasoning requires a basis, which is plausibly provided by a link-based architecture. Moreover, in their attempt to compare two general classes of models (link-based and propositional), Mitchell et al. refer to only two generic models and ignore the large variety of different models within each class.

Athens and Wittenberg explores how Luther and early Lutheranism did not neglect the classics of Greece and Rome, but continued to draw from the philosophy and poetry of antiquity in their quest to reform the church.

This paper provides a method for characterizing space events using the framework of conceptual spaces. We focus specifically on estimating and ranking the likelihood of collisions between space objects. The objective is to design an approach for anticipatory decision support for space operators who can take preventive actions on the basis of assessments of relative risk. To make this possible our approach draws on the fusion of both hard and soft data within a single decision support framework. Contextual data is (...) also taken into account, for example data about space weather effects, by drawing on the Space Domain Ontologies, a large system of ontologies designed to support all aspects of space situational awareness. The framework is coupled with a mathematical programming scheme that frames a mathematically optimal approach for decision support, providing a quantitative basis for ranking potential for collision across multiple satellite pairs. The goal is to provide the broadest possible information foundation for critical assessments of collision likelihood. (shrink)

Les décisions politiques sur les risques environnementaux complexes font fréquemment intervenir des éléments scientifiques contestés. Il n’y a généralement pas de « faits » qui conduisent à une politique correcte unique. Les éléments de preuve qui sont intégrés dans les avis scientifiques destinés à une décision politique nécessitent une évaluation de leur qualité. En 2003, l’Agence néerlandaise d’évaluation environnementale a adopté une méthode standardisée, désignée sous le nom de « guide », dans le cadre de laquelle les principaux aspects de (...) la production et de l’utilisation des connaissances sont présentés grâce à une liste de contrôle visant à l’évaluation et à la communication des incertitudes. Dans cet article, nous présentons des résultats de l’application de ce guide à la controverse sur les risques des particules en suspension. La délibération active sur l’incertitude dans un contexte d’expertise entraîne un processus d’apprentissage commun entre les experts et les décideurs politiques, ce qui conduit à une meilleure prise de conscience du phénomène d’incertitude et de ses implications politiques.Policy decisions on complex environmental risks often involve disputed science. Typically, there are no “ facts” to support a single unequivocally correct policy. The evidence provided in scientific studies for policy-making decisions requires high-quality assessment. In 2003, the Netherlands Environmental Assessment Agency adopted a standardized method, referred to as “guidelines”, whereby key quality aspects of knowledge production and use are presented in the form of a checklist for uncertainty assessments and communication. In this article, we present the outcomes of applying the guidelines in controversies on the risks of ambient particulate matter. In the policy–advisory context, active deliberation on uncertainty produces a common learning process for advisors and policy makers, which leads to a deeper understanding and increased awareness of the phenomenon of uncertainty and its policy implications. (shrink)

Abstract:We analyzed data from a survey of employees of a large military base in order to assess possible differences in the whistle-blowing process due to type of wrongdoing observed. Employees who observed perceived wrongdoing involving mismanagement, sexual harassment, or unspecified legal violations were significantly more likely to report it than were employees who observed stealing, waste, safety problems, or discrimination. Further, type of wrongdoing was significantly related to reasons given by employees who observed wrongdoing but did not report it, across (...) all forms of wrongdoing. However, the primary reason that observers did not report it was that they thought nothing could be done to rectify the situation. Finally, type of wrongdoing was significantly related to the cost of the wrongdoing, the quality of the evidence about the wrongdoing, and the comprehensiveness of retaliation against the whistle-blower. These findings suggest that type of wrongdoing makes a difference in the whistle-blowing process, and it should be examined in future research. (shrink)

The overall goal of the approach developed in this paper is to estimate the likelihood of a given kinetic kill scenario between hostile spacebased adversaries using the mathematical framework of Complex Conceptual Spaces Single Observation. Conceptual spaces are a cognitive model that provide a method for systematically and automatically mimicking human decision making. For accurate decisions to be made, the fusion of both hard and soft data into a single decision framework is required. This presents several challenges to this data (...) fusion framework. The first is the challenge involved in handling multiple complex terminologies, which is addressed by drawing on a set of Space Domain Ontologies. Another challenge is the complex combinatorics involved when considering all possible feature combinations. This can be mitigated by using integer linear programming optimization that is outlined by the Complex Conceptual Spaces Single Observation mathematical model framework. A third challenge is the complicated physics that is involved in a spacecraft collision that must be addressed to obtain a better understanding of threat assessment. Overcoming these various challenges allows for a quantitative ranking for the potential of a kinetic kill collision across multiple spacecraft pairs. In addition to overcoming these challenges this paper will break down threat assessment into four domains and identify a ranking of threat both for each individual domain and for the four domains combined. Simulation results are shown to verify the developed concepts. (shrink)

ABSTRACTEmployees who possess cross-cultural capabilities are increasingly sought after due to unparalleled numbers of cross-cultural interactions. Previous research has primarily focused on the bright side of these capabilities, including important individual and work outcomes. In contrast, the purpose of this study is to demonstrate that the cross-cultural capability of cultural intelligence can lead to both positive and negative outcomes. Applying the general theory of confluence, we propose that expatriates high in CQ excel in customer relationship performance, while simultaneously behaving opportunistically. (...) We also suggest that ethical relativism moderates these relationships. Using mixed methods, four separate studies generally support our predictions while also deepening our understanding of various forms of opportunism and the mechanism behind two seemingly opposing effects. Conceptual and managerial implications of CQ for opportunism, customer relationship performance, and ethics are discussed. (shrink)

Given that university faculty members and supervisors practicing in the community have been involved in at least one research supervisor-graduate student relationship, it is surprising that so little attention has been paid to the ethical issues involved in such relationships. Indeed, as a student and her or his graduate research supervisor may be involved in a close working relationship for many years, it is understandable that several opportunities can arise that could be considered dual or multiple relationships. Examples of such (...) relationship issues discussed in this article include authorship matters, favoritism or inequitable treatment of students, and sexual relationships. Depending on the nature of the relationship, the impact on students can be quite severe; although, the effects on students have not been adequately studied. Existing ethical guidelines do not provide enough guidance in this area where students are in a position of diminished power with respect to the supervisor. Following the discussion of relationship issues, we suggest extensions of current guidelines to deal with these issues. (shrink)

When the Covid‐19 pandemic reached the United States in spring 2020, many states and hospitals announced crisis standards of care plans that used age as a categorical exclusion criterion. Such age choosing was quickly flagged as discriminatory, and so some states and hospitals shifted to embedding age as a tiebreaker deeper in their plans. Different rationales were given for using age as a tiebreaker: that younger patients were more likely to survive than older patients, that saving younger patients would save (...) more life years, and that younger patients deserved a chance to live through life's stages. We provide a critical analysis of these three rationales, noting the differences between them, and then questioning the ethical and legal justifications for such age choosing. (shrink)

The regulation of narcotic medications used in narcotic addiction treatment is unique in medical therapeutics. Physicians who want to use narcotics for this indication must obtain a separate annual registration from the Drug Enforcement Administration. Annual registration is contingent on compliance with both the DEA's security regulations as well as treatment regulations jointly promulgated by the Food and Drug Administration and the National Institute on Drug Abuse.During the last decade, a number of events have occurred that persuaded NIDA that it (...) is time to reevaluate the current method by which the Department of Health and Human Services regulates methadone treatment. As a result of research during the past twenty years, we have learned about the effective components of methadone treatment. In comparison to other available treatment modalities for opioid addiction, methadone treatment is uniquely effective when administered by well-trained medical staffs. (shrink)

The regulation of narcotic medications used in narcotic addiction treatment is unique in medical therapeutics. Physicians who want to use narcotics for this indication must obtain a separate annual registration from the Drug Enforcement Administration. Annual registration is contingent on compliance with both the DEA's security regulations as well as treatment regulations jointly promulgated by the Food and Drug Administration and the National Institute on Drug Abuse.During the last decade, a number of events have occurred that persuaded NIDA that it (...) is time to reevaluate the current method by which the Department of Health and Human Services regulates methadone treatment. As a result of research during the past twenty years, we have learned about the effective components of methadone treatment. In comparison to other available treatment modalities for opioid addiction, methadone treatment is uniquely effective when administered by well-trained medical staffs. (shrink)